AFC Leopards
| AFC Leopards | 1 - 0 | Tusker FC | 26/09/21 |
| KCB FC | 0 - 0 | AFC Leopards | 16/10/21 |
| AFC Leopards | 0 - 1 | Gor Mahia | 20/10/21 |
| Bandari FC | 2 - 1 | AFC Leopards | 24/10/21 |
| AFC Leopards | 0 - 2 | Ulinzi Stars | 29/10/21 |
| Sofapaka | 1 - 0 | AFC Leopards | 07/11/21 |
| Bidco United FC | 1 - 0 | AFC Leopards | 04/12/21 |
| AFC Leopards | 1 - 0 | Posta Rangers | 09/12/21 |
| Vihiga Bullets FC | 1 - 1 | AFC Leopards | 12/12/21 |
| Talanta FC | 1 - 1 | AFC Leopards | 19/12/21 |
Kakamega Homeboyz
| Kakamega Homeboyz | 1 - 0 | Kenya Police FC | 26/09/21 |
| Wazito FC | 0 - 1 | Kakamega Homeboyz | 17/10/21 |
| Kakamega Homeboyz | 2 - 0 | Posta Rangers | 24/10/21 |
| Vihiga Bullets FC | 2 - 3 | Kakamega Homeboyz | 31/10/21 |
| Kakamega Homeboyz | 1 - 1 | Bandari FC | 07/11/21 |
| Nzoia Sugar | 0 - 1 | Kakamega Homeboyz | 04/12/21 |
| Kakamega Homeboyz | 2 - 2 | Mathare United FC | 08/12/21 |
| Bidco United FC | 0 - 0 | Kakamega Homeboyz | 11/12/21 |
| Kakamega Homeboyz | 2 - 1 | Gor Mahia | 18/12/21 |
| Kakamega Homeboyz | 1 - 0 | Tusker FC | 23/12/21 |
AFC Leopards prematch form
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Kakamega Homeboyz prematch form
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