Tusker FC
| AFC Leopards | 1 - 0 | Tusker FC | 26/09/21 |
| Tusker FC | 1 - 2 | Talanta FC | 27/10/21 |
| Tusker FC | 2 - 0 | Wazito FC | 30/10/21 |
| Kenya Police FC | 1 - 2 | Tusker FC | 03/11/21 |
| Kariobangi Sharks | 3 - 0 | Tusker FC | 07/11/21 |
| Tusker FC | 0 - 0 | Sofapaka | 12/12/21 |
| Nzoia Sugar | 0 - 1 | Tusker FC | 19/12/21 |
| Kakamega Homeboyz | 1 - 0 | Tusker FC | 23/12/21 |
| Tusker FC | 4 - 1 | Mathare United FC | 30/12/21 |
| Tusker FC | 2 - 1 | Bidco United FC | 05/01/22 |
| Posta Rangers | 1 - 0 | Tusker FC | 09/01/22 |
| Tusker FC | 0 - 1 | Nairobi City Stars | 16/01/22 |
| Tusker FC | 2 - 0 | Vihiga Bullets FC | 20/01/22 |
| Vihiga Bullets FC | 0 - 0 | Tusker FC | 24/01/22 |
| Tusker FC | 1 - 0 | Bandari FC | 02/02/22 |
| Bandari FC | 0 - 2 | Tusker FC | 06/02/22 |
| Tusker FC | 2 - 0 | Ulinzi Stars | 12/02/22 |
| Ulinzi Stars | 0 - 0 | Tusker FC | 16/02/22 |
| Sofapaka | 0 - 2 | Tusker FC | 25/02/22 |
| Tusker FC | 1 - 1 | Kenya Police FC | 05/03/22 |
| Wazito FC | 0 - 3 | Tusker FC | 08/03/22 |
| Tusker FC | 1 - 0 | Kariobangi Sharks | 12/03/22 |
| KCB FC | 0 - 0 | Tusker FC | 15/03/22 |
| Tusker FC | 1 - 1 | KCB FC | 02/04/22 |
| Tusker FC | 0 - 0 | Gor Mahia | 09/04/22 |
| Gor Mahia | 0 - 2 | Tusker FC | 16/04/22 |
| Talanta FC | 0 - 1 | Tusker FC | 30/04/22 |
| Tusker FC | 2 - 0 | Kakamega Homeboyz | 08/05/22 |
| Nairobi City Stars | 0 - 0 | Tusker FC | 15/05/22 |
| Tusker FC | 2 - 2 | Nzoia Sugar | 22/05/22 |
| Mathare United FC |
-
Suspended |
Tusker FC | 28/05/22 |
| Bidco United FC | 0 - 2 | Tusker FC | 05/06/22 |
| Tusker FC | 2 - 0 | Posta Rangers | 11/06/22 |
AFC Leopards
| AFC Leopards | 2 - 1 | KCB FC | 01/05/22 |
| Gor Mahia | 1 - 1 | AFC Leopards | 08/05/22 |
| AFC Leopards |
2 - 0
Verdict:Win awarded to AFC Leopards |
Kariobangi Sharks | 14/05/22 |
| AFC Leopards | 3 - 2 | Talanta FC | 21/05/22 |
| Kakamega Homeboyz | 0 - 2 | AFC Leopards | 29/05/22 |
| AFC Leopards | 1 - 1 | Nairobi City Stars | 06/06/22 |
| Nzoia Sugar | 3 - 1 | AFC Leopards | 11/06/22 |
Tusker FC prematch form
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AFC Leopards prematch form
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