Mathare United FC
| Bandari FC | 3 - 0 | Mathare United FC | 25/09/21 |
| Mathare United FC | 0 - 1 | Ulinzi Stars | 16/10/21 |
| Sofapaka | 1 - 2 | Mathare United FC | 20/10/21 |
| Nzoia Sugar | 1 - 2 | Mathare United FC | 24/10/21 |
| Mathare United FC | 0 - 6 | Kariobangi Sharks | 31/10/21 |
| Mathare United FC | 0 - 1 | Bidco United FC | 06/11/21 |
| Mathare United FC | 0 - 2 | Talanta FC | 04/12/21 |
| Kakamega Homeboyz | 2 - 2 | Mathare United FC | 08/12/21 |
| Mathare United FC | 0 - 2 | Nairobi City Stars | 11/12/21 |
| Wazito FC | 4 - 1 | Mathare United FC | 19/12/21 |
| Tusker FC | 4 - 1 | Mathare United FC | 30/12/21 |
| Mathare United FC | 0 - 1 | KCB FC | 04/01/22 |
| Gor Mahia | 1 - 0 | Mathare United FC | 09/01/22 |
| Mathare United FC | 1 - 2 | Kenya Police FC | 15/01/22 |
| AFC Leopards | 3 - 1 | Mathare United FC | 20/01/22 |
AFC Leopards
| AFC Leopards | 1 - 0 | Tusker FC | 26/09/21 |
| KCB FC | 0 - 0 | AFC Leopards | 16/10/21 |
| AFC Leopards | 0 - 1 | Gor Mahia | 20/10/21 |
| Bandari FC | 2 - 1 | AFC Leopards | 24/10/21 |
| AFC Leopards | 0 - 2 | Ulinzi Stars | 29/10/21 |
| Sofapaka | 1 - 0 | AFC Leopards | 07/11/21 |
| Bidco United FC | 1 - 0 | AFC Leopards | 04/12/21 |
| AFC Leopards | 1 - 0 | Posta Rangers | 09/12/21 |
| Vihiga Bullets FC | 1 - 1 | AFC Leopards | 12/12/21 |
| Talanta FC | 1 - 1 | AFC Leopards | 19/12/21 |
| AFC Leopards | 2 - 2 | Kakamega Homeboyz | 29/12/21 |
| Nairobi City Stars | 0 - 1 | AFC Leopards | 05/01/22 |
| AFC Leopards | 1 - 1 | Nzoia Sugar | 09/01/22 |
| Kariobangi Sharks | 3 - 1 | AFC Leopards | 15/01/22 |
| AFC Leopards | 3 - 1 | Mathare United FC | 20/01/22 |
| AFC Leopards | 1 - 1 | Bidco United FC | 06/02/22 |
| Posta Rangers | 1 - 3 | AFC Leopards | 13/02/22 |
| AFC Leopards | 0 - 0 | Vihiga Bullets FC | 27/02/22 |
| AFC Leopards | 2 - 2 | Bandari FC | 06/03/22 |
| Ulinzi Stars |
0 - 2
Called Off |
AFC Leopards | 09/03/22 |
| AFC Leopards | 1 - 1 | Sofapaka | 13/03/22 |
| AFC Leopards | 1 - 1 | Kenya Police FC | 20/03/22 |
| Kenya Police FC | 0 - 3 | AFC Leopards | 03/04/22 |
| Wazito FC | 1 - 2 | AFC Leopards | 10/04/22 |
| AFC Leopards | 1 - 1 | Wazito FC | 18/04/22 |
| Tusker FC | 2 - 1 | AFC Leopards | 24/04/22 |
| AFC Leopards | 2 - 1 | KCB FC | 01/05/22 |
| Gor Mahia | 1 - 1 | AFC Leopards | 08/05/22 |
| AFC Leopards |
2 - 0
Verdict:Win awarded to AFC Leopards |
Kariobangi Sharks | 14/05/22 |
| AFC Leopards | 3 - 2 | Talanta FC | 21/05/22 |
| Kakamega Homeboyz | 0 - 2 | AFC Leopards | 29/05/22 |
| AFC Leopards | 1 - 1 | Nairobi City Stars | 06/06/22 |
| Nzoia Sugar | 3 - 1 | AFC Leopards | 11/06/22 |
Mathare United FC prematch form
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AFC Leopards prematch form
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