Kakamega Homeboyz
| Kakamega Homeboyz | 1 - 0 | Kenya Police FC | 26/09/21 |
| Wazito FC | 0 - 1 | Kakamega Homeboyz | 17/10/21 |
| Kakamega Homeboyz | 2 - 0 | Posta Rangers | 24/10/21 |
| Vihiga Bullets FC | 2 - 3 | Kakamega Homeboyz | 31/10/21 |
| Kakamega Homeboyz | 1 - 1 | Bandari FC | 07/11/21 |
| Nzoia Sugar | 0 - 1 | Kakamega Homeboyz | 04/12/21 |
| Kakamega Homeboyz | 2 - 2 | Mathare United FC | 08/12/21 |
| Bidco United FC | 0 - 0 | Kakamega Homeboyz | 11/12/21 |
| Kakamega Homeboyz | 2 - 1 | Gor Mahia | 18/12/21 |
| Kakamega Homeboyz | 1 - 0 | Tusker FC | 23/12/21 |
| AFC Leopards | 2 - 2 | Kakamega Homeboyz | 29/12/21 |
Talanta FC
| Talanta FC | 1 - 1 | Wazito FC | 25/09/21 |
| Talanta FC | 1 - 1 | KCB FC | 20/10/21 |
| Talanta FC | 2 - 0 | Vihiga Bullets FC | 23/10/21 |
| Tusker FC | 1 - 2 | Talanta FC | 27/10/21 |
| Bandari FC | 3 - 0 | Talanta FC | 31/10/21 |
| Ulinzi Stars | 2 - 2 | Talanta FC | 07/11/21 |
| Mathare United FC | 0 - 2 | Talanta FC | 04/12/21 |
| Talanta FC | 2 - 1 | Bidco United FC | 08/12/21 |
| Posta Rangers | 2 - 0 | Talanta FC | 12/12/21 |
| Talanta FC | 1 - 1 | AFC Leopards | 19/12/21 |
| Kariobangi Sharks | 1 - 1 | Talanta FC | 29/12/21 |
| Talanta FC | 1 - 2 | Nairobi City Stars | 08/01/22 |
| Gor Mahia | 2 - 0 | Talanta FC | 16/01/22 |
| Nzoia Sugar | 2 - 3 | Talanta FC | 19/01/22 |
| Talanta FC | 2 - 2 | Nzoia Sugar | 23/01/22 |
| Talanta FC |
-
0-2 result nullified |
Mathare United FC | 05/02/22 |
| Bidco United FC | 0 - 1 | Talanta FC | 12/02/22 |
| Talanta FC | 0 - 1 | Posta Rangers | 27/02/22 |
| Vihiga Bullets FC | 2 - 1 | Talanta FC | 06/03/22 |
| Talanta FC | 0 - 2 | Bandari FC | 09/03/22 |
| Talanta FC | 0 - 0 | Ulinzi Stars | 13/03/22 |
| Sofapaka | 1 - 2 | Talanta FC | 16/03/22 |
| Talanta FC | 0 - 0 | Sofapaka | 03/04/22 |
| Kenya Police FC | 1 - 1 | Talanta FC | 09/04/22 |
| Talanta FC | 2 - 1 | Kenya Police FC | 16/04/22 |
| Wazito FC | 0 - 2 | Talanta FC | 25/04/22 |
| Talanta FC | 0 - 1 | Tusker FC | 30/04/22 |
| KCB FC | 2 - 2 | Talanta FC | 08/05/22 |
| Talanta FC | - | Gor Mahia | 14/05/22 |
| AFC Leopards | 3 - 2 | Talanta FC | 21/05/22 |
| Talanta FC | 2 - 0 | Kariobangi Sharks | 29/05/22 |
| Talanta FC |
0 - 2
Walkover |
Kakamega Homeboyz | 05/06/22 |
| Nairobi City Stars | 2 - 2 | Talanta FC | 11/06/22 |
Kakamega Homeboyz prematch form
D W W D D W D W W W W
Talanta FC prematch form
D D L W W D L W W D D
