Island Panthers
| Roo Simba | 2 - 0 | Island Panthers | 27/02/22 |
| Ukwe FC | 2 - 2 | Island Panthers | 13/03/22 |
| Hotline FC | 2 - 0 | Island Panthers | 27/03/22 |
| Island Panthers | 0 - 1 | Kancha Wazito FC | 03/04/22 |
| Kisegi FC | 2 - 1 | Island Panthers | 10/04/22 |
| Island Panthers | 0 - 4 | Isibania FC | 17/04/22 |
| Island Panthers |
1 - 2
Postponed |
Ringa FC | 24/04/22 |
| Island Panthers | 1 - 2 | One Touch FC | 08/05/22 |
| Nyakurukuma |
2 - 0
Walkover |
Island Panthers | 15/05/22 |
| One Touch FC | 5 - 0 | Island Panthers | 12/06/22 |
| Island Panthers |
2 - 0
Walkover |
Nyakurukuma | 19/06/22 |
| Isibania FC | 2 - 0 | Island Panthers | 03/07/22 |
| Island Panthers | 0 - 2 | Kisegi FC | 10/07/22 |
| Kancha Wazito FC | 0 - 3 | Island Panthers | 17/07/22 |
| Island Panthers | 1 - 1 | Hotline FC | 24/07/22 |
| Island Panthers |
2 - 0
Ukwe pulled out of league |
Ukwe FC | 07/08/22 |
| Island Panthers | 1 - 0 | Roo Simba | 21/08/22 |
| Ringa FC | 1 - 0 | Island Panthers | 28/08/22 |
Hotline FC
| Hotline FC | 2 - 0 | Ukwe FC | 20/02/22 |
| Hotline FC | 1 - 0 | Isibania FC | 06/03/22 |
| Hotline FC | 4 - 1 | Kancha Wazito FC | 13/03/22 |
| Kisegi FC | 0 - 2 | Hotline FC | 20/03/22 |
| Hotline FC | 2 - 0 | Island Panthers | 27/03/22 |
| Hotline FC | 3 - 1 | Nyakurukuma | 10/04/22 |
| One Touch FC | 0 - 0 | Hotline FC | 17/04/22 |
| Ringa FC | 0 - 0 | Hotline FC | 01/05/22 |
| Hotline FC | 0 - 1 | Roo Simba | 08/05/22 |
| Roo Simba | 2 - 1 | Hotline FC | 12/06/22 |
| Hotline FC | 1 - 1 | Ringa FC | 19/06/22 |
| Hotline FC | 1 - 1 | One Touch FC | 03/07/22 |
| Nyakurukuma | 2 - 0 | Hotline FC | 10/07/22 |
| Island Panthers | 1 - 1 | Hotline FC | 24/07/22 |
| Hotline FC | 0 - 2 | Kisegi FC | 31/07/22 |
| Kancha Wazito FC |
0 - 2
Wazito pulled out of league |
Hotline FC | 07/08/22 |
| Ukwe FC | 0 - 2 | Hotline FC | 28/08/22 |
| Isibania FC |
2 - 0
Walkover |
Hotline FC | 04/09/22 |
Island Panthers prematch form
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Hotline FC prematch form
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