Wazito FC
| Talanta FC | 1 - 1 | Wazito FC | 25/09/21 |
| Wazito FC | 0 - 1 | Kakamega Homeboyz | 17/10/21 |
| Nairobi City Stars | 3 - 1 | Wazito FC | 21/10/21 |
| Kariobangi Sharks | 1 - 1 | Wazito FC | 24/10/21 |
| Tusker FC | 2 - 0 | Wazito FC | 30/10/21 |
| Wazito FC | 0 - 2 | KCB FC | 05/11/21 |
| Wazito FC | 1 - 0 | Ulinzi Stars | 04/12/21 |
| Sofapaka | 2 - 1 | Wazito FC | 08/12/21 |
| Wazito FC | 1 - 1 | Kenya Police FC | 11/12/21 |
| Wazito FC | 4 - 1 | Mathare United FC | 19/12/21 |
| Bidco United FC | 1 - 0 | Wazito FC | 30/12/21 |
| Wazito FC | 1 - 4 | Posta Rangers | 05/01/22 |
| Vihiga Bullets FC | 4 - 2 | Wazito FC | 09/01/22 |
| Wazito FC | 2 - 1 | Nzoia Sugar | 16/01/22 |
| Bandari FC | 0 - 1 | Wazito FC | 20/01/22 |
| Wazito FC | 1 - 1 | Bandari FC | 24/01/22 |
| Ulinzi Stars | 1 - 0 | Wazito FC | 05/02/22 |
| Wazito FC | 1 - 2 | Sofapaka | 12/02/22 |
| Kenya Police FC | 2 - 3 | Wazito FC | 26/02/22 |
| Wazito FC | 0 - 3 | Tusker FC | 08/03/22 |
| KCB FC | 2 - 0 | Wazito FC | 12/03/22 |
| Gor Mahia | 1 - 0 | Wazito FC | 19/03/22 |
| Wazito FC | 1 - 2 | Gor Mahia | 02/04/22 |
| Wazito FC | 1 - 2 | AFC Leopards | 10/04/22 |
| AFC Leopards | 1 - 1 | Wazito FC | 18/04/22 |
| Wazito FC | 0 - 2 | Talanta FC | 25/04/22 |
| Kakamega Homeboyz | 1 - 1 | Wazito FC | 01/05/22 |
| Wazito FC | 0 - 1 | Nairobi City Stars | 09/05/22 |
| Nzoia Sugar | 0 - 1 | Wazito FC | 15/05/22 |
| Mathare United FC |
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Suspended |
Wazito FC | 21/05/22 |
| Wazito FC | 0 - 0 | Bidco United FC | 29/05/22 |
| Posta Rangers | 1 - 2 | Wazito FC | 04/06/22 |
| Wazito FC | 2 - 0 | Vihiga Bullets FC | 11/06/22 |
Kariobangi Sharks
| Posta Rangers | 0 - 1 | Kariobangi Sharks | 25/09/21 |
| Vihiga Bullets FC | 0 - 3 | Kariobangi Sharks | 20/10/21 |
| Kariobangi Sharks | 1 - 1 | Wazito FC | 24/10/21 |
| Kariobangi Sharks | 0 - 2 | Gor Mahia | 27/10/21 |
| Mathare United FC | 0 - 6 | Kariobangi Sharks | 31/10/21 |
| Kariobangi Sharks | 3 - 0 | Tusker FC | 07/11/21 |
| Nairobi City Stars | 1 - 2 | Kariobangi Sharks | 04/12/21 |
| Kariobangi Sharks | 1 - 3 | Kenya Police FC | 08/12/21 |
| Nzoia Sugar | 3 - 1 | Kariobangi Sharks | 11/12/21 |
| Bandari FC | 1 - 1 | Kariobangi Sharks | 17/12/21 |
| Kariobangi Sharks | 1 - 1 | Talanta FC | 29/12/21 |
| Ulinzi Stars | 0 - 1 | Kariobangi Sharks | 04/01/22 |
| Kariobangi Sharks | 0 - 1 | Kakamega Homeboyz | 08/01/22 |
| Kariobangi Sharks | 3 - 1 | AFC Leopards | 15/01/22 |
| Sofapaka | 0 - 0 | Kariobangi Sharks | 19/01/22 |
| Kariobangi Sharks | 3 - 0 | Sofapaka | 23/01/22 |
| Kariobangi Sharks | 0 - 1 | Nairobi City Stars | 05/02/22 |
| Kenya Police FC | 0 - 1 | Kariobangi Sharks | 11/02/22 |
| Kariobangi Sharks | 0 - 1 | Nzoia Sugar | 26/02/22 |
| Kariobangi Sharks |
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1-1 result nullified |
Mathare United FC | 09/03/22 |
| Tusker FC | 1 - 0 | Kariobangi Sharks | 12/03/22 |
| Bidco United FC | 1 - 1 | Kariobangi Sharks | 16/03/22 |
| Kariobangi Sharks | 2 - 1 | Bidco United FC | 03/04/22 |
| Kariobangi Sharks | 2 - 2 | KCB FC | 09/04/22 |
| KCB FC | 0 - 2 | Kariobangi Sharks | 17/04/22 |
| Kariobangi Sharks | 3 - 2 | Posta Rangers | 23/04/22 |
| Gor Mahia | 0 - 0 | Kariobangi Sharks | 01/05/22 |
| Kariobangi Sharks | 3 - 4 | Vihiga Bullets FC | 08/05/22 |
| AFC Leopards |
2 - 0
Verdict:Win awarded to AFC Leopards |
Kariobangi Sharks | 14/05/22 |
| Kariobangi Sharks | 0 - 2 | Bandari FC | 22/05/22 |
| Talanta FC | 2 - 0 | Kariobangi Sharks | 29/05/22 |
| Kariobangi Sharks | 0 - 1 | Ulinzi Stars | 04/06/22 |
| Kakamega Homeboyz | 2 - 0 | Kariobangi Sharks | 11/06/22 |
Wazito FC prematch form
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Kariobangi Sharks prematch form
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