Kolwa United
| Tido FC | 1 - 0 | Kolwa United | 31/10/21 |
| Kolwa United | 3 - 2 | Julu Nyabangu FC | 06/11/21 |
| Nyamlori FC | 1 - 0 | Kolwa United | 14/11/21 |
Power Boys FC
| Power Boys FC | 0 - 1 | Nyamlori FC | 14/03/21 |
| Winam FC | 2 - 0 | Power Boys FC | 21/03/21 |
| Power Boys FC | 1 - 3 | Kolwa Allstars | 23/05/21 |
| Kunya FC | 0 - 1 | Power Boys FC | 30/05/21 |
| Power Boys FC | 1 - 2 | Orongo FC | 06/06/21 |
| Power Boys FC | 0 - 2 | The Saints FC | 15/08/21 |
| Kisumu City Stars | 2 - 1 | Power Boys FC | 22/08/21 |
| Power Boys FC | 1 - 0 | Julu Nyabangu FC | 28/08/21 |
| Tido FC | 0 - 1 | Power Boys FC | 29/08/21 |
| Power Boys FC | 2 - 2 | Kianja Allstars FC | 04/09/21 |
| Masawa FC | 0 - 1 | Power Boys FC | 05/09/21 |
| Power Boys FC | 2 - 0 | Kolwa United | 11/09/21 |
| Slum Totos FC | 0 - 1 | Power Boys FC | 12/09/21 |
| Super Strikers FC | 2 - 0 | Power Boys FC | 18/09/21 |
| Power Boys FC |
2 - 0
Walkover |
Masawa FC | 25/09/21 |
| Power Boys FC | 1 - 1 | Winam FC | 26/09/21 |
| Kianja Allstars FC | 1 - 1 | Power Boys FC | 02/10/21 |
| Nyamlori FC | 1 - 0 | Power Boys FC | 03/10/21 |
| Julu Nyabangu FC | 0 - 3 | Power Boys FC | 17/10/21 |
| Power Boys FC | 0 - 1 | Super Strikers FC | 20/10/21 |
| Power Boys FC | 1 - 2 | Kisumu City Stars | 23/10/21 |
| Orongo FC | 0 - 2 | Power Boys FC | 24/10/21 |
| Kolwa Allstars | 0 - 0 | Power Boys FC | 31/10/21 |
| Power Boys FC | 1 - 1 | Tido FC | 06/11/21 |
| Power Boys FC |
-
Suspended |
Kunya FC | 07/11/21 |
| The Saints FC | 8 - 0 | Power Boys FC | 14/11/21 |
| Power Boys FC | 2 - 0 | Slum Totos FC | 14/11/21 |
Kolwa United prematch form
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Power Boys FC prematch form
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