Karapul Villa FC
| Olympic Rangers FC | 2 - 0 | Karapul Villa FC | 30/05/21 |
| Karapul Villa FC | 1 - 1 | Greenland FC | 06/06/21 |
| Humwend FC | 2 - 4 | Karapul Villa FC | 13/06/21 |
| Karapul Villa FC | 2 - 0 | Wazito FC | 22/08/21 |
| Oyundo Galaxy FC | 0 - 2 | Karapul Villa FC | 29/08/21 |
| Karapul Villa FC | 0 - 2 | Ginga FC | 05/09/21 |
| Madungu FC | 3 - 0 | Karapul Villa FC | 12/09/21 |
| Karapul Villa FC | 1 - 3 | TNS FC | 19/09/21 |
| TNS FC | 3 - 0 | Karapul Villa FC | 10/10/21 |
| Karapul Villa FC | 2 - 1 | Olympic Rangers FC | 17/10/21 |
| Karapul Villa FC | 1 - 1 | Madungu FC | 31/10/21 |
| Ginga FC | 0 - 1 | Karapul Villa FC | 07/11/21 |
| Karapul Villa FC | 2 - 0 | Oyundo Galaxy FC | 14/11/21 |
| Wazito FC |
0 - 2
Walkover |
Karapul Villa FC | 21/11/21 |
| Greenland FC |
2 - 0
Walkover |
Karapul Villa FC | 04/12/21 |
Humwend FC
| Humwend FC | 3 - 2 | Oyundo Galaxy FC | 30/05/21 |
| Humwend FC | 1 - 2 | TNS FC | 06/06/21 |
| Humwend FC | 2 - 4 | Karapul Villa FC | 13/06/21 |
| Wazito FC | 1 - 2 | Humwend FC | 15/08/21 |
| Ginga FC | 0 - 2 | Humwend FC | 29/08/21 |
| Humwend FC | 0 - 3 | Madungu FC | 05/09/21 |
| Greenland FC | 1 - 1 | Humwend FC | 12/09/21 |
| Humwend FC | 2 - 2 | Olympic Rangers FC | 19/09/21 |
| TNS FC | 2 - 1 | Humwend FC | 17/10/21 |
| Olympic Rangers FC | 1 - 1 | Humwend FC | 24/10/21 |
| Humwend FC | 3 - 0 | Greenland FC | 31/10/21 |
| Madungu FC | 1 - 0 | Humwend FC | 07/11/21 |
| Humwend FC | 0 - 0 | Ginga FC | 14/11/21 |
| Oyundo Galaxy FC | 0 - 3 | Humwend FC | 21/11/21 |
| Humwend FC |
2 - 0
Walkover |
Wazito FC | 28/11/21 |
Karapul Villa FC prematch form
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Humwend FC prematch form
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