Santos FC
| Kiendege Youngsters | 7 - 1 | Santos FC | 28/02/21 |
| Bogwendo FC | 0 - 1 | Santos FC | 07/03/21 |
| Santos FC | 0 - 4 | Nyaguku FC | 14/03/21 |
| Santos FC | 3 - 0 | Nyambaria Alliance | 21/03/21 |
| Tombe Elites FC | 1 - 2 | Santos FC | 16/05/21 |
| Santos FC | 4 - 0 | Gesure FC | 22/05/21 |
| Santos FC | 1 - 3 | Ekerubo Golden FC | 30/05/21 |
| Santos FC | 3 - 2 | Bogwendo FC | 07/08/21 |
| Nyaguku FC |
-
Abandoned |
Santos FC | 14/08/21 |
| Nyambaria Alliance | 2 - 0 | Santos FC | 22/08/21 |
| Santos FC | 2 - 1 | Kiendege Youngsters | 28/08/21 |
| Ekerubo Golden FC | 3 - 2 | Santos FC | 05/09/21 |
| Santos FC |
0 - 2
Walkover |
Tombe Elites FC | 11/09/21 |
| Gesure FC |
-
Suspended |
Santos FC | 18/09/21 |
Nyaguku FC
| Nyambaria Alliance | 2 - 6 | Nyaguku FC | 28/02/21 |
| Nyaguku FC | 4 - 0 | Ekerubo Golden FC | 06/03/21 |
| Santos FC | 0 - 4 | Nyaguku FC | 14/03/21 |
| Nyaguku FC | 3 - 1 | Tombe Elites FC | 20/03/21 |
| Nyaguku FC | 0 - 1 | Kiendege Youngsters | 15/05/21 |
| Bogwendo FC | 0 - 1 | Nyaguku FC | 23/05/21 |
| Nyaguku FC | 0 - 1 | Gesure FC | 30/05/21 |
| Ekerubo Golden FC | 1 - 0 | Nyaguku FC | 08/08/21 |
| Nyaguku FC |
-
Abandoned |
Santos FC | 14/08/21 |
| Tombe Elites FC | 0 - 1 | Nyaguku FC | 22/08/21 |
| Nyaguku FC | 3 - 1 | Nyambaria Alliance | 28/08/21 |
| Gesure FC |
-
Walkover |
Nyaguku FC | 04/09/21 |
| Kiendege Youngsters |
0 - 2
3-3 result nullified |
Nyaguku FC | 12/09/21 |
| Nyaguku FC | 3 - 1 | Bogwendo FC | 18/09/21 |
Santos FC prematch form
? L L W L ? W L W W W L W L
Nyaguku FC prematch form
W W ? W W ? L L W L W W W W
